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This system involved the administration of anabolic steroids on rats, either orally or by injection (depending on the anabolic steroid being assessed)in order to assess the effects of steroid drugs and their effects on sexual behaviour. Semen quality was also evaluated, and sexual activity was assessed as evidenced by sexual activity patterns and frequency of sexual intercourse. Results Male rats were divided into two groups (n = 10 per group) according to their anabolic steroid treatment groups. The first group received a high dose of testosterone (25 mg/kg) once weekly or twice a day on an as needed basis. The second group was administered a small dose of the anabolic steroid l-carnitine (12mg/kg i.p.) daily in a 3x10x12cm dosing rectangle. The testosterone group was divided into two subsamples based on their response to the treatment: rats given the highest dose of testosterone and treated with l-carnitine were those with the highest sexual activity level. At 12 weeks, the same group was again divided into two groups for the second half of the experiment, and all groups were administered the drug or placebo as needed. At 28 weeks, the testosterone-treated rats were given the highest dose of l-carnitine daily while the asexually abstinent rats did not receive l-carnitine. The sex differences in sexual activity, as expressed by the percentage of ejaculations, were significant based on the sex of the female and male rats as indicated by the means of Student's t-tests. It should be noted that the animals were euthanized on day 28 to prevent loss of the seminal vesicles, which would have been a disadvantage of this method of assessing the sexual behaviour of the animals. Results In the sex of the female rats, the highest dose for treatment, 30 mg/kg i.p., given daily for 11 days produced greater levels of ejaculation by females and more frequent ejaculations in the anabolic steroid-treated rats (P < 0.01). In addition, the percentage of ejaculations (which is a marker for sexual activity) was greater in the rats treated with l-carnitine than in the l-carnitine-treated rats (P < 0.01). Similar articles:

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